The web interfaces, depending on the environment of course, are usually quite speedy (1-7 second load time) with exceptions of a few resources like maps and things. If your website is running slow the first thing I usually do is use the waterfall chart with firefox or IE. Hit F12 while in the browser, access the Profiler and reload the page. It'll show you what is taking so long. Using that data you'll be able to get a decent idea whether the slow down is occurring on the web server or the db. After that you can start digging more.
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